Effect of high molecular weight hyaluronic acid on experimental osteoarthritis
نویسندگان
چکیده
منابع مشابه
Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model.
OBJECTIVES We hypothesized that high-molecular-weight (MW) cross-linked (CL) hyaluronic acid (HA) improves joint lubrication and has an enhanced chondroprotective effect. We examined the histopathological changes and friction coefficients in osteoarthritic knee joints after injecting high-MW CL HA. DESIGN A bilateral anterior cruciate ligament transection (ACLT) model in 20 Japanese white rab...
متن کاملHigh Molecular Weight Hyaluronic Acid Inhibits Fibrosis of Endometrium
BACKGROUND Elevated fibrosis has been found in patients with intrauterine adhesion, which indicates that fibrotic factors may play a critical role in formation of intrauterine adhesion. The aim of this study was to identify the effect of hyaluronic acid (HA) at high and low molecular weight on fibrosis of the endometrium in a mouse model of Asherman's syndrome. MATERIAL AND METHODS Endometrial ...
متن کامل[Treatment of acute full-thickness chondral defects with high molecular weight hyaluronic acid; an experimental model].
PURPOSE To evaluate the effect of 2 different protocols of intra-articular hyaluronic acid (HA, hylan G-F20) to articular cartilage regeneration in acute full-thickness chondral defects. MATERIALS AND METHODS Full-thickness chondral defects of 3 x 6 mm were performed into the lateral femoral condyles of New Zealand rabbits, treated with a single or three doses of HA. The animals were sacrifie...
متن کاملEffect of high molecular weight dextran on experimental hypercholesterolemia.
Thirty ml of 6% dextran (mol wt 70,000) was given intravenously daily to rabbits that were hypercholesterolemic from the ingestion of a 0.5%-cholesterol diet. Serum cholesterol concentrations were reduced from 990 ± 103 mg/100 ml to 676 it 79 mg/100 ml after 3 days and to 331 ± 35 mg/100 ml after 7 days of dextran treatment. With the cessation of dextran infusions, serum cholesterol levels rose...
متن کاملInjectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
BACKGROUND Osteoarthritis (OA) is a common joint disease that causes disabilities in elderly adults. However, few long-lasting pharmacotherapeutic agents with low side effects have been developed to treat OA. We evaluated the therapeutic effects of intra-articular injections of hydrogels containing hyaluronic acid (HA) and doxycycline (DOX) in a rabbit OA model. RESULTS Thirteen week old New ...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1992
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)48872-0